A statistical approach for tracking clonal dynamics in cancer using longitudinal next-generation sequencing data

Motivation: The tumor is composed of different cancer cell population (clones), which continues to adapt to their local microenvironment. the standard method for deconvolution clonal mutation group seeks to identify and estimate the prevalence of each group in the tumor, while taking into account the purity and copy number profile. This method has been applied to a cross-sectional and longitudinal data after removing information about the time of sample collection.
Two key question is how we can combine the information in our analyzes and there are benefits in doing so?
Results: We developed clonal deconvolution method, which combines explicit temporal distance longitudinal tumor samples. By combining the Dirichlet Process Mixture Model Gaussian Process priors and used as an input sequence is rarely collected several samples, our method can reconstruct the temporal profile mutation abundance of each cluster is supported by data as a continuous function of time.
We refer to our method on the whole genome, whole exome and sequencing data targeted from patients with chronic lymphocytic leukemia, the data biopsy fluid of patients with melanoma and synthetic data and we found that combining information about a collection of networks improve the performance of the model, as long as the data volume and complexity is available for the free estimate model parameters. Thus, our approach is very useful when collecting a relatively long sequences of tumor samples feasible, such as in liquid cancers (eg, leukemia) and liquid biopsy.
Bactrian camel population size smaller than the dromedary, and they are distributed in the cold and mountain regions and also at risk of extinction in some countries such as Iran. To identify and investigate genome-wide variation, whole-genome sequencing of two Bactrian camels Iran do with the scope 37.4- and 42.6-fold for the first time. Along with Iran Bactrian camel, sequencing data from two domestic and two Mongolian wild Bactrian camel is stored in the NCBI reanalyzed.

scPADGRN: An asphalt ADMM approach to reconstruct gene regulatory networks dynamically using RNA sequencing data-single cell
development and cell differentiation disease both involve dynamic changes; Therefore, reconstruction of dynamic gene regulatory network (DGRNs) is an important issue but it is difficult in biological systems. With recent advances in single-cell technical RNA sequencing (scRNA-seq), a large volume of data scRNA-seq is being obtained for the various processes. However, current methods of concluding DGRNs of the bulk sample may not be suitable for data-seq scRNA.
In this work, we present scPADGRN, inference DGRN new method using “time-series” scRNA-seq data. scPADGRN combining the method of alternating directions asphalt multiplier by grouping cells for reconstruction DGRN. It shows the advantages in accuracy, robustness and fast convergence. In addition, so-called quantitative index Differentiation Gene Interactions Enrichment (DGIE) served to measure the interaction enrichment of genes related to differentiation.
From the score DGIE of the relevant subnetwork, we conclude that the function of embryonic stem (ES) cells are most active initially and may gradually fade over time. Communication power of genes contribute to note that facilitate the differentiation of cells increased from ES cells differentiated into severe cells.
1L SequaGel UreaGel-6 |
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NAT1146 | Scientific Laboratory Supplies | 1L | EUR 103.74 |
1L SequaGel UreaGel-8 |
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NAT1150 | Scientific Laboratory Supplies | 1L | EUR 103.74 |
1L SequaGel UreaGel Diluent |
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NAT1154 | Scientific Laboratory Supplies | 1L | EUR 49.93 |
sequencing system 20x50 cm |
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ESEQ1200-SYS | Consort | ea | EUR 1842 |
UreaGel 29:1 System 1L Kit |
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NAT1128 | Scientific Laboratory Supplies | EACH | EUR 127.68 |
Filtration System 47mm Complete Assembly |
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5809/KIT | Scientific Laboratory Supplies | EACH | EUR 427.69 |
Corning Reagent Bottle 1L PP |
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1500P-1L | Scientific Laboratory Supplies | PK10 | EUR 118.56 |
BEAKER,1L,PLASTIC,LOW FORM,PP,6/6 |
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1000P-1L | CORNING | 6/pk | EUR 75.6 |
Description: Reusable Plastics; Resuable Beakers |
BEAKER,1L,PLASTIC,LOW FORM,PFA,1/6 |
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1003P-1L | CORNING | 1/pk | EUR 783.6 |
Description: Reusable Plastics; Resuable Beakers |
BEAKER,1L,WITH HANDLE AND SPOUT,PP,12/12 |
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1015P-1L | CORNING | 12/pk | EUR 139.2 |
Description: Reusable Plastics; Resuable Beakers |
Diss Media Conc Hydrochloric Acid 0.01N (1L to 40L) |
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DBC10-1L | Scientific Laboratory Supplies | PK6 | EUR 449.16 |
Diss Media Conc Hydrochloric Acid 0.1N (1L to 40L) |
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DBC11-1L | Scientific Laboratory Supplies | PK6 | EUR 449.16 |
Diss Media Conc K Phosph pH 6.0 (1L to 40L) |
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DBC02-1L | Scientific Laboratory Supplies | PK6 | EUR 449.16 |
Diss Media Conc K Phosph pH 7.2 (1L to 40L) |
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DBC04-1L | Scientific Laboratory Supplies | PK6 | EUR 449.16 |
Diss Media Conc K Phosph pH 7.5 (1L to 40L) |
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DBC05-1L | Scientific Laboratory Supplies | PK6 | EUR 449.16 |
Diss Media Conc Na Lauryl Sulphate 0.50% (1L to 20L) |
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DBC07-1L | Scientific Laboratory Supplies | 1L | EUR 82.08 |
Diss Media Conc K Phosph pH 8.0 (1L to 40L) |
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DBC42-1L | Scientific Laboratory Supplies | PK6 | EUR 449.16 |
SequaGel MD SSCP Kit |
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NAT1170 | Scientific Laboratory Supplies | 1KIT | EUR 217.74 |
SequaGel MD Heteroduplex Kit |
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NAT1172 | Scientific Laboratory Supplies | EACH | EUR 231.42 |
Diss Media Conc K Phosph pH 4.5 (1L of to 40L) |
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DBC40-1L | Scientific Laboratory Supplies | PK6 | EUR 449.16 |
Diss Media Conc K Phosph pH 7.1 (1L of to 40L) |
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DBC41-1L | Scientific Laboratory Supplies | PK6 | EUR 449.16 |
Kinesis Filtration System 300ml/1L; replacement Filter Flask |
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FIL1005 | Scientific Laboratory Supplies | EACH | EUR 88.92 |
EpiNext Bisulfite Sequencing Kit (Illumina) |
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P-1056-12 | EpiGentek | 12 Reactions | EUR 625.9 |
EpiNext Bisulfite Sequencing Kit (Illumina) |
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P-1056-24 | EpiGentek | 24 Reactions | EUR 1225.4 |
EpiNext Bisulfite Sequencing Kit (Illumina) |
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P-1056 | EpiGentek |
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CYLINDER,GRAD,1L,PLASTIC,SINGLE METRIC SCALE,PP,TC W/FUNNEL,1/6 |
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3022P-1L | CORNING | 1/pk | EUR 193.2 |
Description: Reusable Plastics; Reusable Cylinders |
100ML SequaGel Buffer |
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NAT1140 | Scientific Laboratory Supplies | 100ML | EUR 24.97 |
450ML SequaGel XR |
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NAT1160 | Scientific Laboratory Supplies | 450ML | EUR 75.24 |
VOL FLASK,1L,PLASTIC,CLASS A,PMP,24/29 TAPERED PP STOPPER,1/3 |
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5640P-1L | CORNING | 1/pk | EUR 159.6 |
Description: Reusable Plastics; Reusable Volumetric Flasks |
VOL FLASK,1L,PLASTIC,CLASS B,PP,24/29 TAPERED PP STOPPER,1/3 |
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5641P-1L | CORNING | 1/pk | EUR 145.2 |
Description: Reusable Plastics; Reusable Volumetric Flasks |
PinPoint-HR System for Platform Cell Line Generation & Retargeting (includes PIN400A-1, PIN200A-1, PIN510A-1, & PIN600A-1) |
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PIN400A-KIT | SBI | 1 Kit | EUR 3357.6 |
Chymotrypsin for Sequencing grade |
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C4001-010 | GenDepot | 4x25ug | EUR 375.6 |
Chymotrypsin for Sequencing grade |
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C4001-100 | GenDepot | 100ug | EUR 343.2 |
sequencing unit 33x45 cm |
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ESEQ1100-SYS | Consort | ea | EUR 1842 |
Trypin for Mass & Sequencing |
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T9600-025 | GenDepot | 25ug | EUR 174 |
Trypin for Mass & Sequencing |
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T9600-100 | GenDepot | 100ug | EUR 262.8 |
Trypin for Mass & Sequencing |
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T9600-112 | GenDepot | 12x100ug | EUR 1988.4 |
Trypin for Mass & Sequencing |
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T9600-400 | GenDepot | 4x100ug | EUR 781.2 |
PinPoint-FC System for Platform Cell Line Generation & Retargeting (includes PIN300A-1, FC200PA-1, PIN200A-1, PIN510A-1, & PIN600A-1) |
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PIN300A-KIT | SBI | 1 Kit | EUR 3357.6 |
450ML SequaGel UreaGel Concentrate |
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NAT1132 | Scientific Laboratory Supplies | 450ML | EUR 75.24 |
200ML SequaGel UreaGel Buffer |
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NAT1142 | Scientific Laboratory Supplies | 200ML | EUR 28.5 |
450ML SequaGel UreaGel-6 |
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NAT1144 | Scientific Laboratory Supplies | 450ML | EUR 63.84 |
450ML SequaGel UreaGel-8 |
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NAT1148 | Scientific Laboratory Supplies | 450ML | EUR 63.84 |
450ML SequaGel UreaGel Diluent |
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NAT1152 | Scientific Laboratory Supplies | 450ML | EUR 35.68 |
90ML SequaGel Complete Buffer |
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NAT1156 | Scientific Laboratory Supplies | 90ML | EUR 23.83 |
100ML SequaGel XR Concentrate |
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NAT1164 | Scientific Laboratory Supplies | 100ML | EUR 78.66 |
450ML SequaGel XR Concentrate |
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NAT1166 | Scientific Laboratory Supplies | 450ML | EUR 338.58 |
SDS-Blue™ - Coomassie based solution for protein staining in SDS-PAGE |
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04-GSB | Gentaur Genprice |
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Description: SDS-Blue™ is an innovative patented formula, based on Coomassie blue, that comes in a convenient ready to use format for staining proteins in SDS-PAGE (sodium dodecyl sulphate–polyacrylamide gel electrophoresis). The formulation of SDS-Blue™ provides numerous advantages compared to the classic Coomassie staining or to other similar protein stains. SDS-Blue™ provides higher sensitivity, virtually no background and eliminates the need for destaining of the gel due to its high specificity and affinity to bind to protein only. Not only does SDS-Blue™ yield clear and sharp bands, but it also contains no methanol and acetic acid, making it non-hazardous, safe to handle and friendly to the environment when disposed of. Two other advantages that make SDS-Blue™ the better option is that it is not light sensitive and can be stored at ambient temperature for 24 months. And this provides a considerable convenience, especially to laboratories that need and keep big amount of protein staining solutions – no more jammed refrigerators, you can keep SDS-Blue™ wherever it is most convenient for You! |
PinPoint-HR System for Platform Cell Line Generation & Retargeting of AAVS1 Safe Harbor Locus (includes PIN410A-1, GE601A-1, PIN200A-1, PIN510A-1, & PIN600A-1) |
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PIN410A-KIT | SBI | 1 Kit | EUR 5202 |
PinPoint-HR System for Platform Cell Line Generation & Retargeting of AAVS1 Safe Harbor Locus (includes PIN410A-1, CAS601A-1, PIN200A-1, PIN510A-1, & PIN600A-1) |
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PIN412A-KIT | SBI | 1 Kit | EUR 5202 |
DNA Library Prep Kit for IIlumina Sequencing |
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K1475-12 | Biovision | 12 Rxns | EUR 576 |
200ML SequaGel UreaGel Complete Buffer |
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NAT1158 | Scientific Laboratory Supplies | 200ML | EUR 29.75 |
200ML SequaGel MD Monomer Solution |
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NAT1168 | Scientific Laboratory Supplies | 200ML | EUR 181.26 |
MagaDye™ 4 Color Sanger Sequencing Terminator Kit |
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17068 | AAT Bioquest | 5 nmoles | EUR 2091 |
1L Hanna pH 6.86 buffer 1L |
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HI70061L | Scientific Laboratory Supplies | 1L | EUR 29.64 |
1L HarrisHematoxylin |
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NAT1338 | Scientific Laboratory Supplies | 1L | EUR 100.32 |
1L Autofluor |
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NAT1446 | Scientific Laboratory Supplies | 1L | EUR 223.44 |
Sharpsbin 1L |
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SAF7352 | Scientific Laboratory Supplies | EACH | EUR 3.42 |
Percoll 1L |
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17089101 | Scientific Laboratory Supplies | EACH | EUR 425.22 |
PCR Clean Up for DNA Sequencing |
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BT5100 | Bio Basic | 100preps | EUR 114.82 |
PCR Clean Up for DNA Sequencing |
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BT5101 | Bio Basic | 1000Preps, 1000prep | EUR 553.3 |
Frit Kit |
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FRIT-KIT | Next Advance | 1each | EUR 148.8 |
Description: Kit to create frits in capillaries. Includes formamide, Kasil-1, Kasil-1624 and a cleaving tool. |
Watershed System Kit |
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M-WS180320-1 | MiTeGen | 1 KIT | EUR 9296 |
Description: Watershed System Kit |
Column Packing Kit |
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PACK-KIT | Next Advance | 1pack | EUR 1242 |
Description: Column packing kit for pressure cells. Includes: HPREG regulator, TBNG10 tubing, CAP-75 capillary, and STRB5X2 stir bar. |
PCR Mycoplasma Detection Kit |
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M034-Kit | TOKU-E | Kit | EUR 319.2 |
1.2ML SequaGel MD SSCP Stop Solution |
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NAT1174 | Scientific Laboratory Supplies | 1.2ML | EUR 29.75 |
1L Opticlear Sample Kit II |
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NAT1496 | Scientific Laboratory Supplies | 1L | EUR 175.56 |
Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit |
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CAS400A-KIT | SBI | 1 kit (10 rxn) | EUR 1332 |
Pesticide Kit Containing All 10 Multi-Compound Mixes |
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SPXPR-KIT | Scientific Laboratory Supplies | 1ML | EUR 1923.18 |
Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit |
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CAS410A-KIT | SBI | 1 kit (10 rxn) | EUR 798 |
Beaker Brushes, 1L |
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BR007-1K | Bio Basic | 1 UNIT | EUR 64.18 |
SLINGSHOT-1L Antibody |
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48407-100ul | SAB | 100ul | EUR 399.6 |
SLINGSHOT-1L Antibody |
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48407-50ul | SAB | 50ul | EUR 286.8 |
SLINGSHOT-1L Antibody |
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abx016133-100ug | Abbexa | 100 ug | EUR 493.2 |
SLINGSHOT-1L Antibody |
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abx224128-100ug | Abbexa | 100 ug | EUR 493.2 |
1L-chiro-Inositol |
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GC7626-100MG | Glentham Life Sciences | 100 mg | EUR 122.4 |
1L-chiro-Inositol |
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GC7626-1G | Glentham Life Sciences | 1 g | EUR 322.8 |
Dermcidin-1L (human) |
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H-7316.0500 | Bachem | 0.5mg | EUR 212.4 |
Description: Sum Formula: C210H359N57O71; CAS# [478898-18-9] net |
Dermcidin-1L (human) |
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H-7316.1000 | Bachem | 1.0mg | EUR 352.8 |
Description: Sum Formula: C210H359N57O71; CAS# [478898-18-9] net |
1L Flask Clamp |
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MIX1332 | Scientific Laboratory Supplies | EACH | EUR 30.78 |
1L Tween 20 |
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NAT1084 | Scientific Laboratory Supplies | 1L | EUR 124.26 |
1L ProtoBlue Safe |
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NAT1108 | Scientific Laboratory Supplies | 1L | EUR 112.86 |
1L ProtoStain Blue |
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NAT1112 | Scientific Laboratory Supplies | 1L | EUR 118.56 |
1L AcrylaGel 30% |
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NAT1118 | Scientific Laboratory Supplies | 1L | EUR 133.38 |
1L TBE 10X |
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NAT1196 | Scientific Laboratory Supplies | 1L | EUR 44 |
1L TBE 5X |
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NAT1200 | Scientific Laboratory Supplies | 1L | EUR 36.82 |
1L Denaturation Solution |
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NAT1232 | Scientific Laboratory Supplies | 1L | EUR 48.79 |
1L Neutralization Solution |
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NAT1234 | Scientific Laboratory Supplies | 1L | EUR 48.79 |
1L ProtoGel (30%) |
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NAT1260 | Scientific Laboratory Supplies | 1L | EUR 135.66 |
1L ProtoGel (40%) |
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NAT1264 | Scientific Laboratory Supplies | 1L | EUR 161.88 |
1L Scotts Tapwater |
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NAT1342 | Scientific Laboratory Supplies | 1L | EUR 34.54 |
1L Oxosol 306 |
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NAT1382 | Scientific Laboratory Supplies | 1L | EUR 86.64 |
Flask Receiving 1L |
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EVA5012 | Scientific Laboratory Supplies | EACH | EUR 204.06 |
Arsenite 0.05M 1L |
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SA2005F | Scientific Laboratory Supplies | 1L | EUR 101.46 |
Stainless Container 1L |
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SAM1111 | Scientific Laboratory Supplies | EACH | EUR 263.34 |
Scoop 1L Polypropylene |
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SCO1016 | Scientific Laboratory Supplies | EACH | EUR 28.16 |
GL45 Flask - 1L |
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FLA1006 | Scientific Laboratory Supplies | PK10 | EUR 241.68 |
Flask Filter 1L |
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FLA7724 | Scientific Laboratory Supplies | PK5 | EUR 282.12 |
Beaker 1L SSteel |
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BEA3328 | Scientific Laboratory Supplies | EACH | EUR 104.88 |
Percoll Plus 1L |
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17544501 | Scientific Laboratory Supplies | EACH | EUR 641.82 |
Hellmanexcleaning concentrate 1l |
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CEL2106 | Scientific Laboratory Supplies | EACH | EUR 79.8 |
Dosing Bottle 1L |
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CLE2020 | Scientific Laboratory Supplies | EACH | EUR 8.16 |
Sepharose 6B 1L |
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17011001 | Scientific Laboratory Supplies | EACH | EUR 918.84 |
Sepharose 4B 1L |
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17012001 | Scientific Laboratory Supplies | EACH | EUR 918.84 |
Growth Medium 1L |
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79555 | BPS Bioscience | 500 ml | EUR 650 |
Description: This liquid Growth Medium is a complete medium optimized to culture select BPS Bioscience cell lines. |
Cas9-EGFP Protein and T7 gRNA SmartNuclease Synthesis Kit |
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CAS420A-KIT | SBI | 1 kit (10 rxn) | EUR 828 |
CMV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit |
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CASLV100PA-KIT | SBI | 1 Kit | EUR 1358.4 |
CMV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit |
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CASLV105PA-KIT | SBI | 1 Kit | EUR 1358.4 |
MSCV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit |
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CASLV120PA-KIT | SBI | 1 Kit | EUR 1358.4 |
MSCV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit |
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CASLV125PA-KIT | SBI | 1 Kit | EUR 1358.4 |
Multiplex gRNA Kit + EF1-T7-hspCas9-H1-gRNA linearized SmartNuclease vector |
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CAS700A-KIT | SBI | 10 rxn | EUR 1358.4 |
Multiplex gRNA Kit + CAG-T7-hspCas9-H1-gRNA linearized SmartNuclease vector |
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CAS720A-KIT | SBI | 10 rxn | EUR 1358.4 |
Multiplex gRNA Kit + CMV-T7-hspCas9-H1-gRNA linearized SmartNuclease vector |
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CAS740A-KIT | SBI | 10 rxn | EUR 1358.4 |
T7 gRNA SmartNuclease Synthesis Kit (includes CAS510A-1 & T7 IVT synthesis reagents) |
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CAS510A-KIT | SBI | 1 Kit | EUR 966 |
Cas9 Nickase: CMV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit |
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CASLV200PA-KIT | SBI | 1 Kit | EUR 1358.4 |
Cas9 Nickase: CMV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit |
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CASLV205PA-KIT | SBI | 1 Kit | EUR 1358.4 |
Cas9 Nickase: MSCV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit |
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CASLV220PA-KIT | SBI | 1 Kit | EUR 1358.4 |
Cas9 Nickase: MSCV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit |
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CASLV225PA-KIT | SBI | 1 Kit | EUR 1358.4 |
Multiplex gRNA Kit + Cas9 Nickase: EF1-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector |
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CAS750A-KIT | SBI | 10 rxn | EUR 1358.4 |
Multiplex gRNA Kit + Cas9 Nickase: CAG-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector |
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CAS770A-KIT | SBI | 10 rxn | EUR 1358.4 |
Multiplex gRNA Kit + Cas9 Nickase: CMV-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector |
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CAS790A-KIT | SBI | 10 rxn | EUR 1358.4 |
Human Metallothionein- 1L, MT1L ELISA KIT |
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ELI-36664h | Lifescience Market | 96 Tests | EUR 988.8 |
Human Metallothionein 1L(MT1L)ELISA Kit |
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QY-E02761 | Qayee Biotechnology | 96T | EUR 433.2 |
Cas9 SmartNuclease Extra Ligation Kit [includes 5x ligation buffer (10 ul) and Fast ligase (2.5ul)] |
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CAS9LIG-KIT | SBI | 1 Kit | EUR 183.6 |
Claritas PPT Grade Minerals Testing Kit for ICP-MS 1000 ug/mL (1000 ppm) 6 each 30mL |
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SPXMT-KIT | Scientific Laboratory Supplies | 30ML | EUR 237.12 |
ProtoBlock System |
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NAT1004 | Scientific Laboratory Supplies | 1KIT | EUR 71.82 |
New system |
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VS10WPGS2 | Scientific Laboratory Supplies | EACH | EUR 80.94 |
PinPoint-FC 293T Platform Kit for Targeted Gene Insertion (includes PIN320A-1, PIN200A-1, PIN510A-1 & PIN600A-1) |
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PIN320A-KIT | SBI | 1 Kit | EUR 5929.2 |
Claritas PPT Grade Heavy Metals Testing Kit for ICP-MS 1000 ug/mL (1000 ppm) 6 each 30mL |
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SPXHM-KIT | Scientific Laboratory Supplies | 30ML | EUR 245.1 |
PinPoint-FC Murine iPSC Platform Kit for Targeted Gene Insertion (includes PIN340iPS-1, PIN200A-1, PIN510A-1 & PIN600A-1) |
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PIN340iPS-KIT | SBI | 1 Kit | EUR 5929.2 |
BCA Protein Assay Kit |
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AR0146-1L | BosterBio | 1kit | EUR 547.2 |
SLINGSHOT-1L Conjugated Antibody |
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C48407 | SAB | 100ul | EUR 476.4 |
CELL EXPANSION BAG, 1L |
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91-200-85 | CORNING | 1/pk | EUR 134.4 |
Description: Flexible Containers; Bioprocess Bags and Parts |
InstantBlue 1L (Instant Blue) |
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ISB1L | Expedeon | 1L bottle | EUR 198 |
Kartell Jug 1L PP |
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JUG1002 | Scientific Laboratory Supplies | EACH | EUR 9.12 |
Jug StSteel 1L Graduated |
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JUG2002 | Scientific Laboratory Supplies | EACH | EUR 42.18 |
1L DEPC Treated Water |
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NAT1104 | Scientific Laboratory Supplies | 1L | EUR 69.54 |
1L Bis-AcrylaGel 2% |
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NAT1122 | Scientific Laboratory Supplies | 1L | EUR 60.42 |
1L TAE Buffer 50X |
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NAT1222 | Scientific Laboratory Supplies | 1L | EUR 101.46 |
1L SSC Buffer 20X |
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NAT1224 | Scientific Laboratory Supplies | 1L | EUR 44 |
1L ProtoGel Resolving Buffer |
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NAT1268 | Scientific Laboratory Supplies | 1L | EUR 78.66 |
1L EDTA 0.5M Solution |
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NAT1282 | Scientific Laboratory Supplies | 1L | EUR 140.22 |
Rotating Flask 1L Quickfit |
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QFD1L4RE | Scientific Laboratory Supplies | EACH | EUR 59.91 |
Bibby 1L Heating Mantle |
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HEA6508 | Scientific Laboratory Supplies | EACH | EUR 479.94 |
Ice pan 1L square |
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HOM2736 | Scientific Laboratory Supplies | EACH | EUR 307.8 |
Electrode Storage Soln 1l |
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ESS01 | Scientific Laboratory Supplies | 1L | EUR 107.16 |
Nalgene MF75 Receiver 1L |
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FIL8026 | Scientific Laboratory Supplies | PK12 | EUR 167.58 |
1L Sodium Hydroxide Solution |
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S25001SP | Scientific Laboratory Supplies | 1L | EUR 49.02 |
GL45 Baffled Flask - 1L |
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FLA1016 | Scientific Laboratory Supplies | PK10 | EUR 259.92 |
Simax Buchner Flask 1L |
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FLA38040 | Scientific Laboratory Supplies | PK8 | EUR 471.96 |
Erlenmeyer Flask Narrow 1L |
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FLA40100 | Scientific Laboratory Supplies | PK10 | EUR 66.12 |
Baffled 1L Erlenmeyer Flask |
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FLA4196 | Scientific Laboratory Supplies | EACH | EUR 57.47 |
Nalgene 1L Flask Disposable |
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FLA7116 | Scientific Laboratory Supplies | PK6 | EUR 92.34 |
Pyrex 1L Separating Funnel |
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FUN4126 | Scientific Laboratory Supplies | EACH | EUR 121.09 |
1L TAE Buffer 10x |
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46-010-CM | Scientific Laboratory Supplies | PK6 | EUR 243.96 |
1L Millers LB Broth |
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46-050-CM | Scientific Laboratory Supplies | PK6 | EUR 223.44 |
We also identified some of the genes responsible for the change in the score DGIE occur during cell differentiation is based on three single-cell dataset real. Our results show that single-cell analysis is based on inference network coupled with quantitative calculations can reveal key transcriptional regulators involved in cell differentiation and disease progression.