Motivation: The tumor is composed of different cancer cell population (clones), which continues to adapt to their local microenvironment. the standard method for deconvolution clonal mutation group seeks to identify and estimate the prevalence of each group in the tumor, while taking into account the purity and copy number profile. This method has been applied to a cross-sectional and longitudinal data after removing information about the time of sample collection.

Two key question is how we can combine the information in our analyzes and there are benefits in doing so?
Results: We developed clonal deconvolution method, which combines explicit temporal distance longitudinal tumor samples. By combining the Dirichlet Process Mixture Model Gaussian Process priors and used as an input sequence is rarely collected several samples, our method can reconstruct the temporal profile mutation abundance of each cluster is supported by data as a continuous function of time.

We refer to our method on the whole genome, whole exome and sequencing data targeted from patients with chronic lymphocytic leukemia, the data biopsy fluid of patients with melanoma and synthetic data and we found that combining information about a collection of networks improve the performance of the model, as long as the data volume and complexity is available for the free estimate model parameters. Thus, our approach is very useful when collecting a relatively long sequences of tumor samples feasible, such as in liquid cancers (eg, leukemia) and liquid biopsy.

Bactrian camel population size smaller than the dromedary, and they are distributed in the cold and mountain regions and also at risk of extinction in some countries such as Iran. To identify and investigate genome-wide variation, whole-genome sequencing of two Bactrian camels Iran do with the scope 37.4- and 42.6-fold for the first time. Along with Iran Bactrian camel, sequencing data from two domestic and two Mongolian wild Bactrian camel is stored in the NCBI reanalyzed.

scPADGRN: An asphalt ADMM approach to reconstruct gene regulatory networks dynamically using RNA sequencing data-single cell

development and cell differentiation disease both involve dynamic changes; Therefore, reconstruction of dynamic gene regulatory network (DGRNs) is an important issue but it is difficult in biological systems. With recent advances in single-cell technical RNA sequencing (scRNA-seq), a large volume of data scRNA-seq is being obtained for the various processes. However, current methods of concluding DGRNs of the bulk sample may not be suitable for data-seq scRNA.

In this work, we present scPADGRN, inference DGRN new method using “time-series” scRNA-seq data. scPADGRN combining the method of alternating directions asphalt multiplier by grouping cells for reconstruction DGRN. It shows the advantages in accuracy, robustness and fast convergence. In addition, so-called quantitative index Differentiation Gene Interactions Enrichment (DGIE) served to measure the interaction enrichment of genes related to differentiation.

From the score DGIE of the relevant subnetwork, we conclude that the function of embryonic stem (ES) cells are most active initially and may gradually fade over time. Communication power of genes contribute to note that facilitate the differentiation of cells increased from ES cells differentiated into severe cells.

1L SequaGel UreaGel-6
NAT1146	Scientific Laboratory Supplies	1L	EUR 103.74

1L SequaGel UreaGel-8
NAT1150	Scientific Laboratory Supplies	1L	EUR 103.74

1L SequaGel UreaGel Diluent
NAT1154	Scientific Laboratory Supplies	1L	EUR 49.93

sequencing system 20x50 cm
ESEQ1200-SYS	Consort	ea	EUR 1842

UreaGel 29:1 System 1L Kit
NAT1128	Scientific Laboratory Supplies	EACH	EUR 127.68

Filtration System 47mm Complete Assembly
5809/KIT	Scientific Laboratory Supplies	EACH	EUR 427.69

Corning Reagent Bottle 1L PP
1500P-1L	Scientific Laboratory Supplies	PK10	EUR 118.56

BEAKER,1L,PLASTIC,LOW FORM,PP,6/6
1000P-1L	CORNING	6/pk	EUR 75.6
Description: Reusable Plastics; Resuable Beakers

BEAKER,1L,PLASTIC,LOW FORM,PFA,1/6
1003P-1L	CORNING	1/pk	EUR 783.6
Description: Reusable Plastics; Resuable Beakers

BEAKER,1L,WITH HANDLE AND SPOUT,PP,12/12
1015P-1L	CORNING	12/pk	EUR 139.2
Description: Reusable Plastics; Resuable Beakers

Diss Media Conc Hydrochloric Acid 0.01N (1L to 40L)
DBC10-1L	Scientific Laboratory Supplies	PK6	EUR 449.16

Diss Media Conc Hydrochloric Acid 0.1N (1L to 40L)
DBC11-1L	Scientific Laboratory Supplies	PK6	EUR 449.16

Diss Media Conc K Phosph pH 6.0 (1L to 40L)
DBC02-1L	Scientific Laboratory Supplies	PK6	EUR 449.16

Diss Media Conc K Phosph pH 7.2 (1L to 40L)
DBC04-1L	Scientific Laboratory Supplies	PK6	EUR 449.16

Diss Media Conc K Phosph pH 7.5 (1L to 40L)
DBC05-1L	Scientific Laboratory Supplies	PK6	EUR 449.16

Diss Media Conc Na Lauryl Sulphate 0.50% (1L to 20L)
DBC07-1L	Scientific Laboratory Supplies	1L	EUR 82.08

Diss Media Conc K Phosph pH 8.0 (1L to 40L)
DBC42-1L	Scientific Laboratory Supplies	PK6	EUR 449.16

SequaGel MD SSCP Kit
NAT1170	Scientific Laboratory Supplies	1KIT	EUR 217.74

SequaGel MD Heteroduplex Kit
NAT1172	Scientific Laboratory Supplies	EACH	EUR 231.42

Diss Media Conc K Phosph pH 4.5 (1L of to 40L)
DBC40-1L	Scientific Laboratory Supplies	PK6	EUR 449.16

Diss Media Conc K Phosph pH 7.1 (1L of to 40L)
DBC41-1L	Scientific Laboratory Supplies	PK6	EUR 449.16

Kinesis Filtration System 300ml/1L; replacement Filter Flask
FIL1005	Scientific Laboratory Supplies	EACH	EUR 88.92

EpiNext Bisulfite Sequencing Kit (Illumina)
P-1056	EpiGentek	EUR 1798.26 EUR 625.90 EUR 1225.40	24 Reactions 12 Reactions 24 Reactions

EpiNext Bisulfite Sequencing Kit (Illumina)
P-1056-12	EpiGentek	12 Reactions	EUR 625.9

EpiNext Bisulfite Sequencing Kit (Illumina)
P-1056-24	EpiGentek	24 Reactions	EUR 1225.4

CYLINDER,GRAD,1L,PLASTIC,SINGLE METRIC SCALE,PP,TC W/FUNNEL,1/6
3022P-1L	CORNING	1/pk	EUR 193.2
Description: Reusable Plastics; Reusable Cylinders

PinPoint-HR System for Platform Cell Line Generation & Retargeting (includes PIN400A-1, PIN200A-1, PIN510A-1, & PIN600A-1)
PIN400A-KIT	SBI	1 Kit	EUR 3357.6

100ML SequaGel Buffer
NAT1140	Scientific Laboratory Supplies	100ML	EUR 24.97

450ML SequaGel XR
NAT1160	Scientific Laboratory Supplies	450ML	EUR 75.24

VOL FLASK,1L,PLASTIC,CLASS A,PMP,24/29 TAPERED PP STOPPER,1/3
5640P-1L	CORNING	1/pk	EUR 159.6
Description: Reusable Plastics; Reusable Volumetric Flasks

VOL FLASK,1L,PLASTIC,CLASS B,PP,24/29 TAPERED PP STOPPER,1/3
5641P-1L	CORNING	1/pk	EUR 145.2
Description: Reusable Plastics; Reusable Volumetric Flasks

PinPoint-FC System for Platform Cell Line Generation & Retargeting (includes PIN300A-1, FC200PA-1, PIN200A-1, PIN510A-1, & PIN600A-1)
PIN300A-KIT	SBI	1 Kit	EUR 3357.6

Chymotrypsin for Sequencing grade
C4001-010	GenDepot	4x25ug	EUR 375.6

Chymotrypsin for Sequencing grade
C4001-100	GenDepot	100ug	EUR 343.2

sequencing unit 33x45 cm
ESEQ1100-SYS	Consort	ea	EUR 1842

Trypin for Mass & Sequencing
T9600-025	GenDepot	25ug	EUR 174

Trypin for Mass & Sequencing
T9600-100	GenDepot	100ug	EUR 262.8

Trypin for Mass & Sequencing
T9600-112	GenDepot	12x100ug	EUR 1988.4

Trypin for Mass & Sequencing
T9600-400	GenDepot	4x100ug	EUR 781.2

SDS-Blue™ - Coomassie based solution for protein staining in SDS-PAGE
04-GSB	Gentaur Genprice	EUR 144.00 EUR 96.00	1L 500mL
Description: SDS-Blue™ is an innovative patented formula, based on Coomassie blue, that comes in a convenient ready to use format for staining proteins in SDS-PAGE (sodium dodecyl sulphate–polyacrylamide gel electrophoresis). The formulation of SDS-Blue™ provides numerous advantages compared to the classic Coomassie staining or to other similar protein stains. SDS-Blue™ provides higher sensitivity, virtually no background and eliminates the need for destaining of the gel due to its high specificity and affinity to bind to protein only. Not only does SDS-Blue™ yield clear and sharp bands, but it also contains no methanol and acetic acid, making it non-hazardous, safe to handle and friendly to the environment when disposed of. Two other advantages that make SDS-Blue™ the better option is that it is not light sensitive and can be stored at ambient temperature for 24 months. And this provides a considerable convenience, especially to laboratories that need and keep big amount of protein staining solutions – no more jammed refrigerators, you can keep SDS-Blue™ wherever it is most convenient for You!

PinPoint-HR System for Platform Cell Line Generation & Retargeting of AAVS1 Safe Harbor Locus (includes PIN410A-1, GE601A-1, PIN200A-1, PIN510A-1, & PIN600A-1)
PIN410A-KIT	SBI	1 Kit	EUR 5202

PinPoint-HR System for Platform Cell Line Generation & Retargeting of AAVS1 Safe Harbor Locus (includes PIN410A-1, CAS601A-1, PIN200A-1, PIN510A-1, & PIN600A-1)
PIN412A-KIT	SBI	1 Kit	EUR 5202

450ML SequaGel UreaGel Concentrate
NAT1132	Scientific Laboratory Supplies	450ML	EUR 75.24

200ML SequaGel UreaGel Buffer
NAT1142	Scientific Laboratory Supplies	200ML	EUR 28.5

450ML SequaGel UreaGel-6
NAT1144	Scientific Laboratory Supplies	450ML	EUR 63.84

450ML SequaGel UreaGel-8
NAT1148	Scientific Laboratory Supplies	450ML	EUR 63.84

450ML SequaGel UreaGel Diluent
NAT1152	Scientific Laboratory Supplies	450ML	EUR 35.68

90ML SequaGel Complete Buffer
NAT1156	Scientific Laboratory Supplies	90ML	EUR 23.83

100ML SequaGel XR Concentrate
NAT1164	Scientific Laboratory Supplies	100ML	EUR 78.66

450ML SequaGel XR Concentrate
NAT1166	Scientific Laboratory Supplies	450ML	EUR 338.58

DNA Library Prep Kit for IIlumina Sequencing
K1475-12	Biovision	12 Rxns	EUR 576

200ML SequaGel UreaGel Complete Buffer
NAT1158	Scientific Laboratory Supplies	200ML	EUR 29.75

200ML SequaGel MD Monomer Solution
NAT1168	Scientific Laboratory Supplies	200ML	EUR 181.26

MagaDye™ 4 Color Sanger Sequencing Terminator Kit
17068	AAT Bioquest	5 nmoles	EUR 2091

1L Hanna pH 6.86 buffer 1L
HI70061L	Scientific Laboratory Supplies	1L	EUR 29.64

Frit Kit
FRIT-KIT	Next Advance	1each	EUR 148.8
Description: Kit to create frits in capillaries. Includes formamide, Kasil-1, Kasil-1624 and a cleaving tool.

Percoll 1L
17089101	Scientific Laboratory Supplies	EACH	EUR 425.22

1L HarrisHematoxylin
NAT1338	Scientific Laboratory Supplies	1L	EUR 100.32

1L Autofluor
NAT1446	Scientific Laboratory Supplies	1L	EUR 223.44

Sharpsbin 1L
SAF7352	Scientific Laboratory Supplies	EACH	EUR 3.42

PCR Clean Up for DNA Sequencing
BT5100	Bio Basic	100preps	EUR 114.82

PCR Clean Up for DNA Sequencing
BT5101	Bio Basic	1000Preps, 1000prep	EUR 553.3

Column Packing Kit
PACK-KIT	Next Advance	1pack	EUR 1242
Description: Column packing kit for pressure cells. Includes: HPREG regulator, TBNG10 tubing, CAP-75 capillary, and STRB5X2 stir bar.

Watershed System Kit
M-WS180320-1	MiTeGen	1 KIT	EUR 9296
Description: Watershed System Kit

PCR Mycoplasma Detection Kit
M034-Kit	TOKU-E	Kit	EUR 319.2

1.2ML SequaGel MD SSCP Stop Solution
NAT1174	Scientific Laboratory Supplies	1.2ML	EUR 29.75

1L Opticlear Sample Kit II
NAT1496	Scientific Laboratory Supplies	1L	EUR 175.56

Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit
CAS400A-KIT	SBI	1 kit (10 rxn)	EUR 1332

Pesticide Kit Containing All 10 Multi-Compound Mixes
SPXPR-KIT	Scientific Laboratory Supplies	1ML	EUR 1923.18

CMV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit
CASLV100PA-KIT	SBI	1 Kit	EUR 1358.4

CMV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit
CASLV105PA-KIT	SBI	1 Kit	EUR 1358.4

MSCV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit
CASLV120PA-KIT	SBI	1 Kit	EUR 1358.4

MSCV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit
CASLV125PA-KIT	SBI	1 Kit	EUR 1358.4

Multiplex gRNA Kit + EF1-T7-hspCas9-H1-gRNA linearized SmartNuclease vector
CAS700A-KIT	SBI	10 rxn	EUR 1358.4

Multiplex gRNA Kit + CAG-T7-hspCas9-H1-gRNA linearized SmartNuclease vector
CAS720A-KIT	SBI	10 rxn	EUR 1358.4

Multiplex gRNA Kit + CMV-T7-hspCas9-H1-gRNA linearized SmartNuclease vector
CAS740A-KIT	SBI	10 rxn	EUR 1358.4

SLINGSHOT-1L Antibody
48407-100ul	SAB	100ul	EUR 399.6

SLINGSHOT-1L Antibody
48407-50ul	SAB	50ul	EUR 286.8

SLINGSHOT-1L Antibody
abx016133-100ug	Abbexa	100 ug	EUR 493.2

SLINGSHOT-1L Antibody
abx224128-100ug	Abbexa	100 ug	EUR 493.2

Beaker Brushes, 1L
BR007-1K	Bio Basic	1 UNIT	EUR 64.18

1L-chiro-Inositol
GC7626-100MG	Glentham Life Sciences	100 mg	EUR 122.4

1L-chiro-Inositol
GC7626-1G	Glentham Life Sciences	1 g	EUR 322.8

Dermcidin-1L (human)
H-7316.0500	Bachem	0.5mg	EUR 212.4
Description: Sum Formula: C210H359N57O71; CAS# [478898-18-9] net

Dermcidin-1L (human)
H-7316.1000	Bachem	1.0mg	EUR 352.8
Description: Sum Formula: C210H359N57O71; CAS# [478898-18-9] net

Percoll Plus 1L
17544501	Scientific Laboratory Supplies	EACH	EUR 641.82

Sepharose 6B 1L
17011001	Scientific Laboratory Supplies	EACH	EUR 918.84

Sepharose 4B 1L
17012001	Scientific Laboratory Supplies	EACH	EUR 918.84

Beaker 1L SSteel
BEA3328	Scientific Laboratory Supplies	EACH	EUR 104.88

1L Flask Clamp
MIX1332	Scientific Laboratory Supplies	EACH	EUR 30.78

1L Tween 20
NAT1084	Scientific Laboratory Supplies	1L	EUR 124.26

1L ProtoBlue Safe
NAT1108	Scientific Laboratory Supplies	1L	EUR 112.86

1L ProtoStain Blue
NAT1112	Scientific Laboratory Supplies	1L	EUR 118.56

1L AcrylaGel 30%
NAT1118	Scientific Laboratory Supplies	1L	EUR 133.38

1L TBE 10X
NAT1196	Scientific Laboratory Supplies	1L	EUR 44

1L TBE 5X
NAT1200	Scientific Laboratory Supplies	1L	EUR 36.82

1L Denaturation Solution
NAT1232	Scientific Laboratory Supplies	1L	EUR 48.79

1L Neutralization Solution
NAT1234	Scientific Laboratory Supplies	1L	EUR 48.79

1L ProtoGel (30%)
NAT1260	Scientific Laboratory Supplies	1L	EUR 135.66

1L ProtoGel (40%)
NAT1264	Scientific Laboratory Supplies	1L	EUR 161.88

1L Scotts Tapwater
NAT1342	Scientific Laboratory Supplies	1L	EUR 34.54

1L Oxosol 306
NAT1382	Scientific Laboratory Supplies	1L	EUR 86.64

Dosing Bottle 1L
CLE2020	Scientific Laboratory Supplies	EACH	EUR 8.16

GL45 Flask - 1L
FLA1006	Scientific Laboratory Supplies	PK10	EUR 241.68

Flask Filter 1L
FLA7724	Scientific Laboratory Supplies	PK5	EUR 282.12

Flask Receiving 1L
EVA5012	Scientific Laboratory Supplies	EACH	EUR 204.06

Hellmanexcleaning concentrate 1l
CEL2106	Scientific Laboratory Supplies	EACH	EUR 79.8

Arsenite 0.05M 1L
SA2005F	Scientific Laboratory Supplies	1L	EUR 101.46

Stainless Container 1L
SAM1111	Scientific Laboratory Supplies	EACH	EUR 263.34

Scoop 1L Polypropylene
SCO1016	Scientific Laboratory Supplies	EACH	EUR 28.16

T7 gRNA SmartNuclease Synthesis Kit (includes CAS510A-1 & T7 IVT synthesis reagents)
CAS510A-KIT	SBI	1 Kit	EUR 966

Cas9 Nickase: CMV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit
CASLV200PA-KIT	SBI	1 Kit	EUR 1358.4

Cas9 Nickase: CMV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit
CASLV205PA-KIT	SBI	1 Kit	EUR 1358.4

Cas9 Nickase: MSCV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit
CASLV220PA-KIT	SBI	1 Kit	EUR 1358.4

Cas9 Nickase: MSCV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit
CASLV225PA-KIT	SBI	1 Kit	EUR 1358.4

Multiplex gRNA Kit + Cas9 Nickase: EF1-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector
CAS750A-KIT	SBI	10 rxn	EUR 1358.4

Multiplex gRNA Kit + Cas9 Nickase: CAG-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector
CAS770A-KIT	SBI	10 rxn	EUR 1358.4

Multiplex gRNA Kit + Cas9 Nickase: CMV-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector
CAS790A-KIT	SBI	10 rxn	EUR 1358.4

Cas9 SmartNuclease Extra Ligation Kit [includes 5x ligation buffer (10 ul) and Fast ligase (2.5ul)]
CAS9LIG-KIT	SBI	1 Kit	EUR 183.6

Claritas PPT Grade Minerals Testing Kit for ICP-MS 1000 ug/mL (1000 ppm) 6 each 30mL
SPXMT-KIT	Scientific Laboratory Supplies	30ML	EUR 237.12

PinPoint-FC 293T Platform Kit for Targeted Gene Insertion (includes PIN320A-1, PIN200A-1, PIN510A-1 & PIN600A-1)
PIN320A-KIT	SBI	1 Kit	EUR 5929.2

Claritas PPT Grade Heavy Metals Testing Kit for ICP-MS 1000 ug/mL (1000 ppm) 6 each 30mL
SPXHM-KIT	Scientific Laboratory Supplies	30ML	EUR 245.1

PinPoint-FC Murine iPSC Platform Kit for Targeted Gene Insertion (includes PIN340iPS-1, PIN200A-1, PIN510A-1 & PIN600A-1)
PIN340iPS-KIT	SBI	1 Kit	EUR 5929.2

Human Metallothionein- 1L, MT1L ELISA KIT
ELI-36664h	Lifescience Market	96 Tests	EUR 988.8

Human Metallothionein 1L(MT1L)ELISA Kit
QY-E02761	Qayee Biotechnology	96T	EUR 433.2

ProtoBlock System
NAT1004	Scientific Laboratory Supplies	1KIT	EUR 71.82

New system
VS10WPGS2	Scientific Laboratory Supplies	EACH	EUR 80.94

AAVS1 Safe Harbor Targeting Vector 2.0 - All-Purpose Donor (AAVS1-SA-puro-MCS), Complete Kit with CAS601A-1 (Cas9 SmartNuclease AAVS1-gRNA Targeting Vector) and GE640PR-1 (Junction PCR Primer Mix to confirm AAVS1 integration site)
GE620A-KIT	SBI	1 kit	EUR 2558.4

AAVS1 Safe Harbor Targeting Vector 2.0 - GOI Knock-in Donor (AAVS1-SA-puro-EF1-MCS), Complete Kit with CAS601A-1 (Cas9 SmartNuclease AAVS1-gRNA Targeting Vector) and GE640PR-1 (Junction PCR Primer Mix to confirm AAVS1 integration site)
GE622A-KIT	SBI	1 kit	EUR 2558.4

AAVS1 Safe Harbor Targeting Vector 2.0 - Reporter Knock-in Donor (AAVS1-SA-puro-MCS-GFP), Complete Kit with CAS601A-1 (Cas9 SmartNuclease AAVS1-gRNA Targeting Vector) and GE640PR-1 (Junction PCR Primer Mix to confirm AAVS1 integration site)
GE624A-KIT	SBI	1 kit	EUR 2558.4

BCA Protein Assay Kit
AR0146-1L	BosterBio	1kit	EUR 547.2

CELL EXPANSION BAG, 1L
91-200-85	CORNING	1/pk	EUR 134.4
Description: Flexible Containers; Bioprocess Bags and Parts

SLINGSHOT-1L Conjugated Antibody
C48407	SAB	100ul	EUR 476.4

InstantBlue 1L (Instant Blue)
ISB1L	Expedeon	1L bottle	EUR 198

Sodium Edetate 0.1M 1L
3005900	Scientific Laboratory Supplies	1L	EUR 49.02

Sodium Methoxide 0.1M 1L
3007100	Scientific Laboratory Supplies	1L	EUR 139.08

1L Corning Storage Bottle
431734	Scientific Laboratory Supplies	PK24	EUR 296.4

1L TAE Buffer 10x
46-010-CM	Scientific Laboratory Supplies	PK6	EUR 243.96

1L Millers LB Broth
46-050-CM	Scientific Laboratory Supplies	PK6	EUR 223.44

0.1N Sulphuric Acid 1L
2053	Scientific Laboratory Supplies	EACH	EUR 44.69

Euro Pharmacopoeia Reagent 1L
1045901	Scientific Laboratory Supplies	1L	EUR 283.86

Ph Buffer 7 1L
1070	Scientific Laboratory Supplies	EACH	EUR 29.64

1L DMEM Dulbecos Modification
15-017-CM	Scientific Laboratory Supplies	PK6	EUR 215.46

Sepharose CL-2B 1L
17014001	Scientific Laboratory Supplies	EACH	EUR 882.36

Sepharose CL-4B 1L
17015001	Scientific Laboratory Supplies	EACH	EUR 982.68

Sepharose CL-6B 1L
17016001	Scientific Laboratory Supplies	EACH	EUR 982.68

Beaker Low Form 1L
BEA11200	Scientific Laboratory Supplies	PK10	EUR 156.18

Bottle Alpha 1L Glass
BOT2030	Scientific Laboratory Supplies	PK20	EUR 82.63

Bottle Alpha 1L Amber
BOT2050	Scientific Laboratory Supplies	PK20	EUR 91.88

Kartell Jug 1L PP
JUG1002	Scientific Laboratory Supplies	EACH	EUR 9.12

Jug StSteel 1L Graduated
JUG2002	Scientific Laboratory Supplies	EACH	EUR 42.18

1L DEPC Treated Water
NAT1104	Scientific Laboratory Supplies	1L	EUR 69.54

1L Bis-AcrylaGel 2%
NAT1122	Scientific Laboratory Supplies	1L	EUR 60.42

1L TAE Buffer 50X
NAT1222	Scientific Laboratory Supplies	1L	EUR 101.46

1L SSC Buffer 20X
NAT1224	Scientific Laboratory Supplies	1L	EUR 44

1L ProtoGel Resolving Buffer
NAT1268	Scientific Laboratory Supplies	1L	EUR 78.66

We also identified some of the genes responsible for the change in the score DGIE occur during cell differentiation is based on three single-cell dataset real. Our results show that single-cell analysis is based on inference network coupled with quantitative calculations can reveal key transcriptional regulators involved in cell differentiation and disease progression.