Knowledge-primed neural networks enable biologically interpretable deep learning on single-cell sequencing data

Knowledge-primed neural networks enable biologically interpretable deep learning on single-cell sequencing data

Background: Much learning has emerged as a versatile approach for predicting complex biological phenomena. However, the utility of biological discoveries so far been limited, given that generic neural network in providing some insight into the biological mechanisms that underlie successful predictions.

Here we demonstrate in-depth study on the biological network, where each node has an equivalent molecules, such as proteins or genes, and each edge has a mechanistic interpretation, such as regulatory interactions along the signal path.


Results: With the knowledge-primed neural network (KPNNs), we exploit the ability of deep learning algorithm to assign significant weight in the multi-layered network, thus broadly applicable approach to learning in the interpretation. We present a method of learning that increases the interpretability of KPNNs trained by stabilizing the node weights in the presence of redundancy, improve the interpretability quantitative node weights, and control for connectivity are uneven in biological tissue. We validate KPNNs simulated data with known ground truth and show their practical use and utility in five applications with single-cell biology of RNA-seq data for cancer and immune cells.


Conclusions: We introduce KPNNs as a method that combines the predictive power of deep learning with biological tissue interpretability. While shown here at the single-cell sequencing data, this method is broadly relevant to other research fields in which domain knowledge before it can be represented as a network.


neuroendocrine neoplasms (NENs) is a clinical cancer incomplete diverse and characterized challenging to classify. MicroRNAs (miRNAs) are small regulatory RNAs that can be used to classify cancer. More recently, morphology-based classification framework to evaluate NENs from different anatomical sites proposed by the experts, the need for enhanced integration of molecular data.

Here, we collected 378 miRNA expression profiling to examine the classification of Nen through a comprehensive miRNA profiling and data mining. The following data preprocessing, our final study cohort included 221 and 114 Nen-Nen non samples, representing 15 Nen type of pathological and 5 non-site-matched control group Nen.

 Knowledge-primed neural networks enable biologically interpretable deep learning on single-cell sequencing data
Knowledge-primed neural networks enable biologically interpretable deep learning on single-cell sequencing data

Use Whole Genome Sequencing data for First Silico Evaluation Test Specificity of RT-qPCR Used for SARS-CoV-2 Detection

Disease coronavirus Flow 2019 (COVID-19) pandemic started in December 2019. COVID 19 cases are confirmed by the detection of SARS-CoV-2 RNA in biological samples by RT-qPCR. However, a limited number of SARS-CoV-2 genome is available as RT-qPCR method was first developed in January 2020 to early in silico evaluation of specificity and to verify whether the target locus highly conserved.

Now that the genome data more completely available, we use the tools of bioinformatics filtered and total 4755 publicly available SARS-CoV-2 genome, download at two different time points to evaluate the specificity 12 tests RT-qPCR (comprised of a total of 30 primary and probe sets) used for SARS-CoV-2 detection and the impact of the genetic evolution of the virus’ on four of them.

Trypin for Mass & Sequencing

T9600-100 100ug
EUR 262.8

Trypin for Mass & Sequencing

T9600-112 12x100ug
EUR 1988.4

Trypin for Mass & Sequencing

T9600-400 4x100ug
EUR 781.2

Sequencing Grade V8 Protease

RE014 50ug
EUR 209

Chymotrypsin for Sequencing grade

C4001-010 4x25ug
EUR 375.6

Chymotrypsin for Sequencing grade

C4001-100 100ug
EUR 343.2

Sequencing Grade Modified Trypsin

RE012 100ug
EUR 229

PCR Clean Up for DNA Sequencing

BT5100 100preps
EUR 114.82

PCR Clean Up for DNA Sequencing

BT5101 1000Preps, 1000prep
EUR 553.3

Sequencing Grade Carboxypeptidase B

RE011 100ug
EUR 99

ACES Sequencing Buffer 10X, pH 7.7

21420000-1 1 L
EUR 138.62

ACES Sequencing Buffer 10X, pH 7.7

21420000-2 4 L
EUR 456.17

HCV-N-G3/10 (residues 2-119)

PR-1140 100µg
EUR 300.7
Description: recombinant, E. coli

TBE-Buffer 5X for DNA Sequencing

40121072-1 100 mL
EUR 26.54

TBE-Buffer 5X for DNA Sequencing

40121072-2 500 mL
EUR 44.84

TBE-Buffer 5X for DNA Sequencing

40121072-3 1 L
EUR 72.29

TBE-Buffer 5X for DNA Sequencing

40121072-4 4 L
EUR 192.14

SequaGel Sequencing System 1L Kit - 1KIT

NAT1136 1KIT
EUR 187.65

SequaGel Sequencing System 2.2L Kit - EACH

NAT1138 EACH
EUR 318.6

Bovine Trypsin Purified Sequencing Grade

IBOTRYSEQ100UG each
EUR 148
Description: Bovine Trypsin Purified Sequencing Grade

Bovine Trypsin Purified Sequencing Grade

IBOTRYSEQ1MG each
EUR 765
Description: Bovine Trypsin Purified Sequencing Grade

Bovine Trypsin Purified Sequencing Grade

IBOTRYSEQ400UG each
EUR 419
Description: Bovine Trypsin Purified Sequencing Grade

EpiNext Bisulfite Sequencing Kit (Illumina)

P-1056
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  • 24 Reactions
  • 12 Reactions
  • 24 Reactions

DNA Library Prep Kit for IIlumina Sequencing

K1475-12 12 Rxns
EUR 576

HCV-N-G4 (residues 2-119)

PR-1137 100µg
EUR 300.7
Description: recombinant, E. coli

HCV-N-G5 (residues 2-119)

PR-1138 100µg
EUR 300.7
Description: recombinant, E. coli

HCV-N-G1a (residues 2-119)

PR-1130 100µg
EUR 300.7
Description: recombinant, E. coli

HCV-N-G1b (residues 2-119)

PR-1132 100µg
EUR 300.7
Description: recombinant, E. coli

HCV-N-G2b (residues 2-119)

PR-1134 100µg
EUR 300.7
Description: recombinant, E. coli

HCV-N-G3a (residues 2-119)

PR-1135 100µg
EUR 300.7
Description: recombinant, E. coli

HCV-N-G3b (residues 2-119)

PR-1136 100µg
EUR 300.7
Description: recombinant, E. coli

HCV-N-G6a (residues 2-119)

PR-1139 100µg
EUR 300.7
Description: recombinant, E. coli

Bovine Trypsin Purified Sequencing Grade Lyophilized

IBOTRYSEQLY100UG each
EUR 130
Description: Bovine Trypsin Purified Sequencing Grade Lyophilized

Bovine Trypsin Purified Sequencing Grade Lyophilized

IBOTRYSEQLY1MG each
EUR 640
Description: Bovine Trypsin Purified Sequencing Grade Lyophilized

Bovine Trypsin Purified Sequencing Grade Lyophilized

IBOTRYSEQLY400UG each
EUR 344
Description: Bovine Trypsin Purified Sequencing Grade Lyophilized

HCV-N-G2a (residues 2-119)GST

PR-1133 100µg
EUR 300.7
Description: recombinant, E. coli

Genorise® Customized PCR primers for cloning and sequencing

GR108023 2 nmol
EUR 65

RV gE2 (residues 31-105)

PR-1229 100µg
EUR 300.7
Description: recombinant, E. coli

RV-C (residues 1-123)

PR-1230 100µg
EUR 300.7
Description: recombinant, E. coli

TG MIC3 (residues 234-306)

PR-1243 100µg
EUR 300.7
Description: Toxoplasma gondii, recombinant, E. coli

Anti-TAF2(N-terminal-middle residues) Polyclonal Antibody

AB1J129 0.1mg
EUR 399

EBV-EA (residues 306-390)

PR-1224 100µg
EUR 300.7
Description: recombinant, E. coli

CMV pp28 (residues 130-160)

PR-1248 100µg
EUR 300.7
Description: recombinant, E. coli

CMV pp65 (residues 297-510)

PR-1251 100µg
EUR 300.7
Description: recombinant, E. coli

HAV-P2C (residues 1121-1234)

PR-1115 100µg
EUR 300.7
Description: recombinant, E. coli

HAV-P3C (residues 1643-1743)

PR-1121 100µg
EUR 300.7
Description: recombinant, E. coli

SARS-ACM (residues 182-216)

PR-1101 100µg
EUR 300.7
Description: recombinant, E. coli

HEV-ORF3 (residues 92-123)

PR-1187 100µg
EUR 300.7
Description: recombinant, E. coli

AF6-RBDGST (residues 1-141)

PR-398 50µg
EUR 271.4
Description: human, recombinant, E. coli

SARS-ACE (residues 1-76)

PR-1100 100µg
EUR 300.7
Description: recombinant, E. coli

HIV-1 Nef (residues 3-190)

PR-1214 100µg
EUR 300.7
Description: recombinant, E. coli

TG GRA1/p24 (residues 57-149)

PR-1244 100µg
EUR 300.7
Description: Toxoplasma gondii, recombinant, E. coli

TG GRA7/p29 (residues 24-100)

PR-1245 100µg
EUR 300.7
Description: Toxoplasma gondii, recombinant, E. coli

Clenbuterol Residues [BSA]

DAGA-004B 1mg
EUR 936

Clenbuterol Residues [HRP]

DAGA-004H 1mg
EUR 1404

Clenbuterol Residues [KLH]

DAGA-004K 1mg
EUR 1248

Bovine Alpha Chymotrypsin 3X Crystallized TLCK Treated Sequencing Grade

IBOCHYTLCKSG100UG each
EUR 297
Description: Bovine Alpha Chymotrypsin 3X Crystallized TLCK Treated Sequencing Grade

SARS-ACN/1 (residues 340-390)

PR-1102 100µg
EUR 300.7
Description: recombinant, E. coli

HAV-VP1-P2A (residues 722-830)

PR-1113 100µg
EUR 300.7
Description: recombinant, E. coli

HAV-VP1-P2A (residues 669-782)

PR-1114 100µg
EUR 300.7
Description: recombinant, E. coli

HAV-P2C-P3B (residues 1492-1606)

PR-1118 100µg
EUR 300.7
Description: recombinant, E. coli

HAV-VP4-VP2 (residues 55-164)

PR-1120 100µg
EUR 300.7
Description: recombinant, E. coli

SARS-ACN/2 (residues 1-49)

PR-1103 100µg
EUR 300.7
Description: recombinant, E. coli

VZV ORF9 (residues 6-28/76-100)

PR-1254 100µg
EUR 300.7
Description: recombinant, E. coli

VZV ORF26 (residues 9-33/184-208)

PR-1255 100µg
EUR 300.7
Description: recombinant, E. coli

Histone H3 Peptide (residues 15-39) 

R-1005
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  • 200 µl
  • 100 ul
  • 200 ul

HBV-Core 18 kDa (residues 1-183)

PR-1123 100µg
EUR 300.7
Description: recombinant, E. coli

Histone H3 Peptide (residues 1-21) 

R-1003
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  • 400 µl
  • 200 ul
  • 400 ul

Bacteria-Derived Clostripain (Endoproteinase-Arg-C) Sequencing Grade Purified

IBCTCLOSGPF10UG each
EUR 165
Description: Bacteria-Derived Clostripain (Endoproteinase-Arg-C) Sequencing Grade Purified

Bacteria-Derived V8 Protease (Endoprotease Glu-C) Sequencing Grade Lyophilized

IBCTV8SEQLY250UG each
EUR 784
Description: Bacteria-Derived V8 Protease (Endoprotease Glu-C) Sequencing Grade Lyophilized

Bacteria-Derived V8 Protease (Endoprotease Glu-C) Sequencing Grade Lyophilized

IBCTV8SEQLY50UG each
EUR 304
Description: Bacteria-Derived V8 Protease (Endoprotease Glu-C) Sequencing Grade Lyophilized

SARS-ACN/3 (residues 1-49/192-220)

PR-1104 100µg
EUR 300.7
Description: recombinant, E. coli

Clenbuterol residues ELISA Kit

DEIANJ44 96T
EUR 1039.2
Description: This ELISA kit is used for quantitative determination of Clenbuterol residues.

SARS-ACSMS(M) (residues 408-470/540-573)

PR-1106 100µg
EUR 300.7
Description: recombinant, E. coli

HTLV-1 Mosaic (residues 374-400/190-207)

PR-1221 100µg
EUR 300.7
Description: recombinant, E. coli

HBV-Core delta 14 kDa (residues 1-144)

PR-1124 100µg
EUR 300.7
Description: recombinant, E. coli

EBV-EBNA1 Mosaic (residues 1-90/408-498)

PR-1223 100µg
EUR 300.7
Description: recombinant, E. coli

RV gE1 Mosaic (residues 157-176/374-390/213-239)

PR-1228 100µg
EUR 300.7
Description: recombinant, E. coli

Histone H3 Peptide (residues 21-44), Biotinylated

R-1006
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  • 200 µl
  • 100 ul
  • 200 ul

Histone H3 Peptide (residues 69-89), Biotinylated

R-1057 200 µl
EUR 267.06

Sulfonamides residues (SAs) ELISA Kit

AE81013SF-48Tests 48 Tests
EUR 245
Description: Food Safety

Sulfonamides residues (SAs) ELISA Kit

AE81013SF-96Tests 96 Tests
EUR 450
Description: Food Safety

Sulfonamides residues (SAs) ELISA Kit

RDFS-SAs-48T 48T
EUR 488
Description: Animal tissue, aquatic tissue, honey, etc.

Sulfonamides residues (SAs) ELISA Kit

RDFS-SAs-96T 96T
EUR 698
Description: Animal tissue, aquatic tissue, honey, etc.

SARS-ACSMS(C) (residues 1051-1076/1121-1154/1162-1190)

PR-1105 100µg
EUR 300.7
Description: recombinant, E. coli

Histone H3 Peptide (residues 1-21), Biotinylated

R-1004
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  • 200 µl
  • 100 ul
  • 200 ul

Histone H4 Peptide (residues 1-21), Biotinylated

R-1007
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  • 200 µl
  • 100 ul
  • 200 ul

Sulfonamides residues ELISA Kit (OKAO00112)

OKAO00112 96 Wells
EUR 669.6
Description: Description of target: The related sulfinamides (R(S=O)NHR) are amides of sulfinic acids (R(S=O)OH) (see sulfinyl). Chiral sulfinamides such as tert-butanesulfinamide, p-toluenesulfinamide and 2,4,6-trimethylbenzenesulfinamide are relevant to asymmetric synthesis.;Species reactivity: General;Application: ;Assay info: Assay Methodology: Competitive Inhibition ELISA;Sensitivity:
ComponentAmount
Tissue0.4 ppb
Honey, egg0.4 ppb
Serum, urine1.6 ppb
Milk8 ppb

Sulfonamides residues (SAs) ELISA Test Kit

LSY-10009 96 well/kit Ask for price

Anti- HBB(Middle residues) Polyclonal Antibody

AB5FOBP2 0.1mg
EUR 399

Anti- OGCP(Middle residues) Polyclonal Antibody

AB2E152 0.1mg
EUR 399

OKAO00112-96W - Sulfonamides residues ELISA Kit

OKAO00112-96W 96Wells
EUR 475

Anti-NDR1(Middle residues) Polyclonal Antibody

AB2D122 0.1mg
EUR 399

Anti-NFKB2 (Middle residues)Polyclonal Antibody

AB2A103 0.1mg
EUR 399

Anti-IKBKB(Middle residues) Polyclonal Antibody

AB2B017 0.1mg
EUR 399

SEPTA MAT, FOR 96 WELL PCR PLATES, SILICONE, GREY, NONSTERILE, FOR ABI MULTI-CAPILLARY SEQUENCING INSTRUMENTS, BULK

AM-96-SEPTA-3100 10/pk
EUR 639.6
Description: Sealing Products; Sealing mats - Axygen

Anti-GDF-15(Middle residues) Polyclonal Antibody

AB1G192 0.1mg
EUR 399

Anti- Protein J5(Middle residues) Polyclonal Antibody

AB3J073 0.1mg
EUR 399

Anti-IKBKB(Near middle residues) Polyclonal Antibody

AB2B0111 0.1mg
EUR 399

Anti-IKBKB(Near middle residues) Polyclonal Antibody

AB2B019 0.1mg
EUR 399

Anti-EHV-1(Middle residues) GP2 Polyclonal Antibody

AB1G101 0.1mg
EUR 399

Anti-Capsid protein VP1(Middle residues) Polyclonal Antibody

AB2A242 0.1mg
EUR 399

Rat Tuberoinfundibular peptide of 39 residues (PTH2) ELISA Kit

abx549789-96tests 96 tests
EUR 687.5

Anti-Tail Sheath Protein(Middle residues) Polyclonal Antibody

AB2G115 0.1mg
EUR 399

Mouse Tuberoinfundibular peptide of 39 residues, Pth2 ELISA KIT

ELI-45863m 96 Tests
EUR 1038

Human Tuberoinfundibular peptide of 39 residues, PTH2 ELISA KIT

ELI-17166h 96 Tests
EUR 988.8

Human Tuberoinfundibular peptide of 39 residues (PTH2) ELISA Kit

abx549787-96tests 96 tests
EUR 687.5

Mouse Tuberoinfundibular peptide of 39 residues (PTH2) ELISA Kit

abx549788-96tests 96 tests
EUR 687.5

Bovine Tuberoinfundibular peptide of 39 residues, PTH2 ELISA KIT

ELI-28806b 96 Tests
EUR 1113.6

TruStrip RDT Sulfonamides residues (SAs) rapid test strips, results is 2-10 mins, 50 strips/pk

DE-100090-RDT 1 pk
EUR 781.2

pmTFP1-NT(N terminal tag)

ABP-FP-TNNCS 5 ug Ask for price

pLanRFP-NT(N terminal tag)

ABP-FP-RNNCS 5 ug Ask for price

pLanYFP-NT(N terminal tag)

ABP-FP-YNNCS 5 ug Ask for price

pmWasabi-NT(N terminal tag)

ABP-FP-WNNCS 5 ug Ask for price

Caspase-3 (N terminal region)

RA21012 100 ug
EUR 428.4

pmTFP1-NT(N terminal tag)-PuroR

ABP-FP-TNNCSP 5 ug Ask for price

pLanRFP-NT(N terminal tag)-PuroR

ABP-FP-RNNCSP 5 ug Ask for price

pLanYFP-NT(N terminal tag)-PuroR

ABP-FP-YNNCSP 5 ug Ask for price

pmWasabi-NT(N terminal tag)-PuroR

ABP-FP-WNNCSP 5 ug Ask for price

Cleaved GSDMD (N Terminal) Rabbit mAb

A22523 200μL
EUR 128.7
Description: A synthetic peptide corresponding to a sequence within amino acids 232-331 of human NUDC (Q9Y266).

Anti- CXCR4 N terminal Mouse Antibody

GWB-B13A74 0.2 mg Ask for price

Parathyroid Hormone Antibody / N Terminal

V3644-100UG 100 ug
EUR 349.3
Description: PTH/Parathyroid hormone is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V3644-20UG 20 ug
EUR 153.3
Description: PTH/Parathyroid hormone is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V3644IHC-7ML 7 ml
EUR 349.3
Description: PTH/Parathyroid hormone is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V3644SAF-100UG 100 ug
EUR 349.3
Description: PTH/Parathyroid hormone is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V3645-100UG 100 ug
EUR 349.3
Description: PTH/Parathyroid hormone is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V3645-20UG 20 ug
EUR 153.3
Description: PTH/Parathyroid hormone is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V3645IHC-7ML 7 ml
EUR 349.3
Description: PTH/Parathyroid hormone is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V3645SAF-100UG 100 ug
EUR 349.3
Description: PTH/Parathyroid hormone is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V3765-100UG 100 ug
EUR 349.3
Description: Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide containing 84 amino acids, yet effective hormone-receptor interaction requires solely the 34-N-terminal amino acids. While PTH acts to increase the concentration of ionic calcium (Ca2+) in the blood, calcitonin, a hormone produced by the parafollicular cells (C cells) of the thyroid gland, acts to decrease ionic calcium concentration. [Wiki]

Parathyroid Hormone Antibody / N Terminal

V3765-20UG 20 ug
EUR 153.3
Description: Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide containing 84 amino acids, yet effective hormone-receptor interaction requires solely the 34-N-terminal amino acids. While PTH acts to increase the concentration of ionic calcium (Ca2+) in the blood, calcitonin, a hormone produced by the parafollicular cells (C cells) of the thyroid gland, acts to decrease ionic calcium concentration. [Wiki]

Parathyroid Hormone Antibody / N Terminal

V3765IHC-7ML 7 ml
EUR 349.3
Description: Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide containing 84 amino acids, yet effective hormone-receptor interaction requires solely the 34-N-terminal amino acids. While PTH acts to increase the concentration of ionic calcium (Ca2+) in the blood, calcitonin, a hormone produced by the parafollicular cells (C cells) of the thyroid gland, acts to decrease ionic calcium concentration. [Wiki]

Parathyroid Hormone Antibody / N Terminal

V3765SAF-100UG 100 ug
EUR 349.3
Description: Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide containing 84 amino acids, yet effective hormone-receptor interaction requires solely the 34-N-terminal amino acids. While PTH acts to increase the concentration of ionic calcium (Ca2+) in the blood, calcitonin, a hormone produced by the parafollicular cells (C cells) of the thyroid gland, acts to decrease ionic calcium concentration. [Wiki]

Parathyroid Hormone Antibody / N Terminal

V7272-100UG 100 ug
EUR 349.3
Description: PTH/Parathyroid hormone is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V7272-20UG 20 ug
EUR 153.3
Description: PTH/Parathyroid hormone is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V7272IHC-7ML 7 ml
EUR 349.3
Description: PTH/Parathyroid hormone is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V7272SAF-100UG 100 ug
EUR 349.3
Description: PTH/Parathyroid hormone is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V2806-100UG 100 ug
EUR 424.15
Description: PTH is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V2806-20UG 20 ug
EUR 186.15
Description: PTH is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V2806IHC-7ML 7 ml
EUR 424.15
Description: PTH is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V2806SAF-100UG 100 ug
EUR 424.15
Description: PTH is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V2807-100UG 100 ug
EUR 424.15
Description: Epitope of this mAb maps in the N-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V2807-20UG 20 ug
EUR 186.15
Description: Epitope of this mAb maps in the N-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V2807IHC-7ML 7 ml
EUR 424.15
Description: Epitope of this mAb maps in the N-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V2807SAF-100UG 100 ug
EUR 424.15
Description: Epitope of this mAb maps in the N-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V2808-100UG 100 ug
EUR 424.15
Description: PTH is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V2808-20UG 20 ug
EUR 186.15
Description: PTH is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V2808IHC-7ML 7 ml
EUR 424.15
Description: PTH is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V2808SAF-100UG 100 ug
EUR 424.15
Description: PTH is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V3375-100UG 100 ug
EUR 424.15
Description: PTH/Parathyroid hormone is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V3375-20UG 20 ug
EUR 186.15
Description: PTH/Parathyroid hormone is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Parathyroid Hormone Antibody / N Terminal

V3375SAF-100UG 100 ug
EUR 424.15
Description: PTH/Parathyroid hormone is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Anti-Gasdermin D (N terminal) Antibody

ER1901-37 100ul
EUR 189
Description: Gasdermin-D, N-terminal: Promotes pyroptosis in response to microbial infection and danger signals. Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators. After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to phosphatidic acid and phosphatidylserine. Homooligomerizes within the membrane and forms pores of 10 - 15 nanometers (nm) of inner diameter, possibly allowing the release of mature IL1B and triggering pyroptosis . Exhibits bactericidal activity. Gasdermin-D, N-terminal released from pyroptotic cells into the extracellular milieu rapidly binds to and kills both Gram-negative and Gram-positive bacteria, without harming neighboring mammalian cells, as it does not disrupt the plasma membrane from the outside due to lipid-binding specificity.

Rat phospho c Jun N terminal kinase 1

E01A16065 96T
EUR 700
Description: ELISA

Goat phospho c Jun N terminal kinase 1

E01A50968 96T
EUR 700
Description: ELISA

Sheep phospho c Jun N terminal kinase 1

E01A103262 96T
EUR 700
Description: ELISA

Mouse phospho c Jun N terminal kinase 1

E01A24812 96T
EUR 700
Description: ELISA

Alkyne Phosphoramidite, 5'-terminal, 10 g

82260 10 g
EUR 918

Anti-NOTCH 1 (Cleaved N terminal) Antibody

GWB-5F385A 200 ul Ask for price

Exclusivity This method was also assessed using the human reference genome and the genomes of closely related 2624 other respiratory viruses. Specificity of this test is generally good and stable over time. The exception is the method was first developed by the Chinese Center for Disease Control and Prevention (CDC), which showed three primary discrepancy is present in 358 SARS-CoV-2 genome sequencing, especially in Europe from February 2020 onwards.

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